Shared sugars - parasite glycan homology in HIV-1 vaccine design
Autor/innen
- L.P. Deimel
- Q.J. Sattentau
Journal
- Trends in Parasitology
Quellenangabe
- Trends Parasitol 38 (7): 498-500
Zusammenfassung
Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.