© Pixabay Hübner Lab Genetics and Genomics of Cardiovascular Diseases Profile Team Research Publications News Profile Team Research Publications News Profile Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531 Research Medical Genomics and Genetics of Cardiovascular and Metabolic Diseases Publications February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch October 03, 2022 / Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut October 01, 2022 / Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney September 29, 2022 / PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon August 11, 2022 / Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon Pagination First page « First Previous page ‹‹ … Page 2 Current page 3 Page 4 Page 5 … Next page ›› Last page Last » News Press Release No. 23 October 16, 2017 Berlin MDC receives funding to collaborate on Human Cell Atlas Organs and tissues are comprised of very different types of cells. The heart, for example, contains... Press Release No. 21 September 24, 2017 Berlin Study of transplanted hearts reveals risk gene for cardiovascular disease In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future. Science January 23, 2017 Two Humboldt award winners are coming to the MDC as visiting scientists David H. Gutmann, the US neurologist, and Prof. Maike Sander, a diabetes researcher at the University of California, San Diego, USA, have now been granted the Humboldt Research Award by the Alexander von Humboldt Foundation. Science December 15, 2016 Only apparently healthy: How titin gene mutations affect heart function The MDC research group led by Norbert Hübner has discovered that mutations in the titin gene have previously unknown effects on the heart function of healthy individuals. These mutations are present in one percent of the general population. Science November 21, 2016 New multinational study reveals titin gene mutations affect heart function in healthy individuals A new multinational study by researchers from Singapore, the UK and Germany has discovered that gene mutations in a protein called titin affect the heart function in healthy individuals. It was previously thought that the mutations affect only patients with dilated cardiomyopathy, one of the most common forms of inherited heart disease. Science December 18, 2015 By Russell Hodge Finding the regulators Eleonora Adami of the Hübner lab links the regulation of protein synthesis to disease in the best PhD student paper of 2015 Science September 28, 2015 MDC Alumna Henriette Uhlenhaut: “Getting things moving in health research” Nina Henriette Uhlenhaut really gets around. The well-traveled biotechnologist has worked in Braunschweig, Atlanta, Heidelberg, La Jolla, Berlin, and now Munich. During this time, Uhlenhaut’s research has also taken leaps and bounds, covering topics ranging from the molecular biology of plants to the regulation of genes that determine sex in mammals, to human hormone receptors. Science September 01, 2015 New level of gene regulation plays a role in cardiovascular diseases When genes are read at the wrong time or in the wrong place they can cause a disease. Less well... Press Release No. 11 June 16, 2015 Berlin Slight Differences – New Insights into the Regulation of Disease-Associated Genes When a gene is read, its blueprint for proteins encoded in the language of DNA is transcribed in the... Science October 20, 2014 By Russell Hodge A broken tool and broken hearts The analysis of the human genome showed that our DNA contains fewer genes than most scientists... Pagination First page « First Previous page ‹‹ Page 1 Page 2 Current page 3 Page 4 Page 5 Next page ›› Last page Last » Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1) Research Topics Genetics & Genomics Gene Expression Regulation & RNA Biology Cardiovascular Research
Team Group Leader Prof. Dr. Norbert Hübner 87: Timoféeff-Ressovsky-Haus Room: 0.09 nhuebner@mdc-berlin.de +49 30 9406-2530 Scientist Dr. Eleonora Adami Eleonora.Adami@mdc-berlin.de Dr. med. Alena Laschtowitz 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Ning Liang 87: Timoféeff-Ressovsky-Haus Room: 0.10 Ning.Liang@mdc-berlin.de +49 30 9406-4384 Natalia López Anguita 87: Timoféeff-Ressovsky-Haus Room: 0.13 Natalia.LopezAnguita@mdc-berlin.de Dr. Henrike Maatz 87: Timoféeff-Ressovsky-Haus Room: 0.06 h.maatz@mdc-berlin.de +49 30 9406-3037 Dr. Alvaro Perdomo Sabogal Alvaro.Perdomo@mdc-berlin.de Dr. Jorge Ruiz Orera 87: Timoféeff-Ressovsky-Haus Room: 0.17 Jorge.RuizOrera@mdc-berlin.de +49 30 9406-2930 Dr. Kathrin Saar 84: Hermann-von-Helmholtz-Haus Room: 1104 ksaar@mdc-berlin.de +49 30 9406-3534 Secretariat Sabine Meier 87: Timoféeff-Ressovsky-Haus Room: 0.07 Sabine.Meier@mdc-berlin.de +49 30 9406-3512 Technical Assistants Susanne Blachut 87: Timoféeff-Ressovsky-Haus Room: 0.50 s.Blachut@mdc-berlin.de +49 30 9406-3269 Mathias Gerhard 87: Timoféeff-Ressovsky-Haus Room: 0.13 Dr. Giannino Patone 87: Timoféeff-Ressovsky-Haus Room: 0.10 Giannino.Patone@mdc-berlin.de +49 30 9406-3441 Sabine Schmidt 87: Timoféeff-Ressovsky-Haus Room: 0.22 PhD student Nikita Shyam Dewani 87: Timoféeff-Ressovsky-Haus Room: 0.17 Nikita.Dewani@mdc-berlin.de +49 30 9406-3430 Johannes Greiner 87: Timoféeff-Ressovsky-Haus Room: 0.13 Johannes.Greiner@mdc-berlin.de +49 30 9406-2531 Laura Anne Liebig 87: Timoféeff-Ressovsky-Haus Room: 0.13 LauraAnne.Liebig@mdc-berlin.de +49 30 9406-2531 Anna Myronova 87: Timoféeff-Ressovsky-Haus Room: 0.13 Anna.Myronova@mdc-berlin.de +49 30 9406-2531 Nikolay Shvetsov 87: Timoféeff-Ressovsky-Haus Room: 0.13 Nikolay.Shvetsov@mdc-berlin.de +49 30 9406-2531
Publications February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch October 03, 2022 / Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut October 01, 2022 / Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney September 29, 2022 / PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon August 11, 2022 / Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon Pagination First page « First Previous page ‹‹ … Page 2 Current page 3 Page 4 Page 5 … Next page ›› Last page Last »
February 01, 2023 / J Cardiovasc Transl Res LINC01013 is a determinant of fibroblast activation and encodes a novel fibroblast-activating micropeptide N.M. Quaife S. Chothani J.F. Schulz E.L. Lindberg K. Vanezis E. Adami K. O'Fee J. Greiner M. Litviňuková S. van Heesch N. Whiffin N. Hubner S. Schafer O. Rackham S.A. Cook P.J.R. Barton
December 06, 2022 / Circulation Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage M. Ercu M.B. Mücke T. Pallien L. Markó A. Sholokh C. Schächterle A. Aydin A. Kidd S. Walter Y. Esmati B.J. McMurray D.F. Lato D.Y. Sunaga-Franze P.H. Dierks B.I.M. Flores R. Walker-Gray M. Gong C. Merticariu K. Zühlke M. Russwurm T. Liu T.U.P. Batolomaeus S. Pautz S. Schelenz M. Taube H. Napieczynska A. Heuser J. Eichhorst M. Lehmann D.C. Miller S. Diecke F. Qadri E. Popova R. Langanki M.A. Movsesian F.W. Herberg S.K. Forslund D.N. Müller T. Borodina P.G. Maass S. Bähring N. Hübner M. Bader E. Klussmann
December 05, 2022 / Nat Commun Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease A.A. Widjaja S. Viswanathan S.G. Shekeran E. Adami W.W. Lim S. Chothani J. Tan J.W.T. Goh H.M. Chen S.Y. Lim C.M. Boustany-Kari J. Hawkins E. Petretto N. Hübner S. Schafer T.M. Coffman S.A. Cook
December 01, 2022 / NAR Genom Bioinform AntiSplodge: a neural-network-based RNA-profile deconvolution pipeline designed for spatial transcriptomics J.B. Lund E.L. Lindberg H. Maatz F. Pottbaecker N. Hübner C. Lippert
November 11, 2022 / Nat Commun pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation O. Boix M. Martinez S. Vidal M. Giménez-Alejandre L. Palenzuela L. Lorenzo-Sanz L. Quevedo O. Moscoso J. Ruiz-Orera P. Ximénez-Embún N. Ciriaco P. Nuciforo C. Stephan-Otto Attolini M.M. Albà J. Muñoz T.V. Tian I. Varela A. Vivancos S. Ramón Y Cajal P. Muñoz C. Rivas M. Abad
October 06, 2022 / Mol Cel SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA S. Maharana S. Kretschmer S. Hunger X. Yan D. Kuster S. Traikov T. Zillinger M. Gentzel S. Elangovan P. Dasgupta N. Chappidi N. Lucas K.I. Maser H. Maatz A. Rapp V. Marchand Y.T. Chang Y. Motorin N. Hubner G. Hartmann A.A. Hyman S. Alberti M.A. Lee-Kirsch
October 03, 2022 / Comput Struct Biotechnol J Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes S.A. Ansari W. Dantoft J. Ruiz-Orera A.P. Syed S. Blachut S. van Heesch N. Hübner N.H. Uhlenhaut
October 01, 2022 / Hum Mutat Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function S.J. Lin B. Vona H.M. Porter M. Izadi K. Huang Y. Lacassie J.A. Rosenfeld S. Khan C. Petree T.A. Ali N. Muhammad S.A. Khan N. Muhammad P. Liu M.L. Haymon F. Rüschendorf I.K. Kong L. Schnapp N. Shur L. Chorich L. Layman T. Haaf E. Pourkarimi H.G. Kim G.K. Varshney
September 29, 2022 / PLoS ONE Aging-regulated TUG1 is dispensable for endothelial cell function A.T. Gimbel S. Koziarek K. Theodorou J.F. Schulz L. Stanicek V. Kremer T. Ali S. Günther S. Kumar H. Jo N. Hübner L. Maegdefessel S. Dimmeler S. van Heesch R.A. Boon
August 11, 2022 / Eur J Hum Genet Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study S. Konigorski J. Janke G. Patone M.M. Bergmann C. Lippert N. Hübner R. Kaaks H. Boeing T. Pischon
News Press Release No. 23 October 16, 2017 Berlin MDC receives funding to collaborate on Human Cell Atlas Organs and tissues are comprised of very different types of cells. The heart, for example, contains... Press Release No. 21 September 24, 2017 Berlin Study of transplanted hearts reveals risk gene for cardiovascular disease In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future. Science January 23, 2017 Two Humboldt award winners are coming to the MDC as visiting scientists David H. Gutmann, the US neurologist, and Prof. Maike Sander, a diabetes researcher at the University of California, San Diego, USA, have now been granted the Humboldt Research Award by the Alexander von Humboldt Foundation. Science December 15, 2016 Only apparently healthy: How titin gene mutations affect heart function The MDC research group led by Norbert Hübner has discovered that mutations in the titin gene have previously unknown effects on the heart function of healthy individuals. These mutations are present in one percent of the general population. Science November 21, 2016 New multinational study reveals titin gene mutations affect heart function in healthy individuals A new multinational study by researchers from Singapore, the UK and Germany has discovered that gene mutations in a protein called titin affect the heart function in healthy individuals. It was previously thought that the mutations affect only patients with dilated cardiomyopathy, one of the most common forms of inherited heart disease. Science December 18, 2015 By Russell Hodge Finding the regulators Eleonora Adami of the Hübner lab links the regulation of protein synthesis to disease in the best PhD student paper of 2015 Science September 28, 2015 MDC Alumna Henriette Uhlenhaut: “Getting things moving in health research” Nina Henriette Uhlenhaut really gets around. The well-traveled biotechnologist has worked in Braunschweig, Atlanta, Heidelberg, La Jolla, Berlin, and now Munich. During this time, Uhlenhaut’s research has also taken leaps and bounds, covering topics ranging from the molecular biology of plants to the regulation of genes that determine sex in mammals, to human hormone receptors. Science September 01, 2015 New level of gene regulation plays a role in cardiovascular diseases When genes are read at the wrong time or in the wrong place they can cause a disease. Less well... Press Release No. 11 June 16, 2015 Berlin Slight Differences – New Insights into the Regulation of Disease-Associated Genes When a gene is read, its blueprint for proteins encoded in the language of DNA is transcribed in the... Science October 20, 2014 By Russell Hodge A broken tool and broken hearts The analysis of the human genome showed that our DNA contains fewer genes than most scientists... Pagination First page « First Previous page ‹‹ Page 1 Page 2 Current page 3 Page 4 Page 5 Next page ›› Last page Last »
Press Release No. 23 October 16, 2017 Berlin MDC receives funding to collaborate on Human Cell Atlas Organs and tissues are comprised of very different types of cells. The heart, for example, contains...
Press Release No. 21 September 24, 2017 Berlin Study of transplanted hearts reveals risk gene for cardiovascular disease In the largest transcriptome study to date, an international research team analysed the RNA of transplanted hearts and discovered a number of new risk factors for dilated cardiomyopathy and other heart conditions which could thus be recognised more easily in future.
Science January 23, 2017 Two Humboldt award winners are coming to the MDC as visiting scientists David H. Gutmann, the US neurologist, and Prof. Maike Sander, a diabetes researcher at the University of California, San Diego, USA, have now been granted the Humboldt Research Award by the Alexander von Humboldt Foundation.
Science December 15, 2016 Only apparently healthy: How titin gene mutations affect heart function The MDC research group led by Norbert Hübner has discovered that mutations in the titin gene have previously unknown effects on the heart function of healthy individuals. These mutations are present in one percent of the general population.
Science November 21, 2016 New multinational study reveals titin gene mutations affect heart function in healthy individuals A new multinational study by researchers from Singapore, the UK and Germany has discovered that gene mutations in a protein called titin affect the heart function in healthy individuals. It was previously thought that the mutations affect only patients with dilated cardiomyopathy, one of the most common forms of inherited heart disease.
Science December 18, 2015 By Russell Hodge Finding the regulators Eleonora Adami of the Hübner lab links the regulation of protein synthesis to disease in the best PhD student paper of 2015
Science September 28, 2015 MDC Alumna Henriette Uhlenhaut: “Getting things moving in health research” Nina Henriette Uhlenhaut really gets around. The well-traveled biotechnologist has worked in Braunschweig, Atlanta, Heidelberg, La Jolla, Berlin, and now Munich. During this time, Uhlenhaut’s research has also taken leaps and bounds, covering topics ranging from the molecular biology of plants to the regulation of genes that determine sex in mammals, to human hormone receptors.
Science September 01, 2015 New level of gene regulation plays a role in cardiovascular diseases When genes are read at the wrong time or in the wrong place they can cause a disease. Less well...
Press Release No. 11 June 16, 2015 Berlin Slight Differences – New Insights into the Regulation of Disease-Associated Genes When a gene is read, its blueprint for proteins encoded in the language of DNA is transcribed in the...
Science October 20, 2014 By Russell Hodge A broken tool and broken hearts The analysis of the human genome showed that our DNA contains fewer genes than most scientists...
Prof. Dr. Norbert Hübner Group Leader Contact nhuebner@mdc-berlin.de Phone: +49 30 9406-2530 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Robert-Rössle-Straße 10 13125 Berlin, Deutschland Building 87, Room 0.09 Norbert Hübner is a DZHK Principal Investigator Internal affiliations Genes, Cells and Cell‑based Medicine (topic 1)