Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

Biochemist and physician Leif S. Ludwig of the Berlin Institute of Health at Charité (BIH) and the Max Delbrück Center has been named a recipient of the 2023 Heinz Maier-Leibnitz Prize, as the German Research Foundation (DFG) announced on June 27th.

Neuroblastoma is the third most common malignancy in children. 16 labs at the Max Delbrück Center and other Berlin-based researchers will investigate how they originate and grow in a new Collaborative Research Centre. The project, supported by the German Research Foundation (DFG), has been granted approximately €13.5 million.

Since the beginning of the COVID-19 pandemic, researchers have been working on mucosal vaccines that can be administered through the nose. Now, scientists in Berlin have developed a live attenuated vaccine for the nose. In “Nature Microbiology”, they describe the special immune protection it induces.

Chromatin factors are involved in regulating gene expression. If they do not function properly, this can result in neurological impairments. Ana Pombo and Alexander Kukalev are now receiving almost €400,000 from the DFG for a research project that aims to shed more light on how these factors work.

With its "Back to the roots" Lab, the Max Delbrück Center aims to enable young international researchers to become ambassadors for Research in Germany in their home countries. It is one of the winners of the DFG Community Prize.

Errors in cellular RNA metabolism are dangerous for nerve cells. For her work in this area, Marina Chekulaeva has now been accepted into the DFG Heisenberg program.

The heart can get weak in different ways. One form of the disease, heart failure with preserved ejection fraction (HFpEF), continues to be extremely difficult to treat. MDC researchers are involved in a new Collaborative Research Center, where they aim to change this and develop therapeutic approaches.

In cases of severe COVID-19, the lungs develop unusually pronounced scarring, scientists from Berlin, Aachen and Würzburg report in “Cell”. Macrophages are central to this process. Misguided wound healing responses resulting in scarring may explain why COVID-19 patients remain in respiratory failure for so long.

Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy.

Viruses come and go – most of the time, at least. Some, however, stay around forever. A team led by Markus Landthaler at the MDC intends to find out what enables viruses to set up home permanently in a host, as part of the DFG Research Unit DEEP-DV.